The Analytical Ultracentrifuge Fluorescence Detection System (AU-FDS) accessory for the Beckman XL-A / XL-I instruments compliments the existing detectors.

• High Sensitivity (picomolar sample concentrations)
• Large Dynamic Range (approximately four decades)
• High Selectivity (measures only fluorescing molecules)
• Higher Throughput (both sample and reference channels can be loaded with sample)

The FDS works as an add-on to existing Beckman analytical ultracentrifuges, old or new. The original Beckman instrument operation is not affected. The AU-FDS utilizes confocal optics to track the location of fluorophores. High-speed electronics measure the entire rotor rotation, allowing all samples to be measured simultaneously.

The Analytical Ultracentrifuge Advanced Operating System (AU-AOS) controls the instrument’s operation:
• Intuitive Windows graphical user interface, with wizards to set up experiments.
• Supports nearly all Beckman and third party rotors and centerpieces.
• Controls all fluorescence detector operations.
• Controls centrifuge’s speed, temperature and vacuum.
• Fast data collection on ALL samples simultaneously.
• Supports both sedimentation equilibrium and velocity experiments.

• Higher sensitivity and large dynamic range allow determination of tighter binding constants.
• Very high selectivity due to selection of excitation wavelength (488 nm) allows studies with complex mixtures that traditional detectors can not cope with: heterogeneous binding of proteins with the same molecular weight; serum, cell lysates, et cetera.
• 1 1/2 minute scan time for all samples allows faster migrating species to be measured.